- Service: Mechanical
- Location: Alberta (various locations)
- Multiple Pressure Gradients Achieved
Multiple pressure gradients were achieved between zones.
Compounding Rooms are used in pharmacies to create specialized, individualized medications by mixing pharmacy drugs in specific ratios as required by the patient.
The NAPRA Guidance model specifies the updated requirements for the compounding of non-sterile preparations. Such preparations are to be conducted in NSHD (Non-sterile Hazardous) rooms which are called Level C rooms. Level C rooms need a minimum of 12 ACH of continuous ventilation and a minimum negative pressure of 2.5 Pa relative to surrounding rooms. Level C rooms should not be contiguous with the general pharmacy area but should be separated from the general pharmacy area by a buffer zone called a Level B room. Level B rooms need to be well-ventilated with ideally 6 ACH and neutral pressurization.
All compounding in Level C rooms are to be conducted in a containment device/ fume hood (CPEC – Containment Primary Engineering Control). The fume hoods can draw air from the room and recirculate it back into the room after double HEPA filtration.
The Level C (C-SEC) room serves as a secondary containment unit for the compounding activities.
The air from level C rooms cannot be recirculated in the general pharmacy and should be duly exhausted after a single level of HEPA filtration.
We designed multiple compounding rooms with a negative pressurization of -12.5 Pa ( 5x requirement) and 20 ACH for the Level C Areas and 8 ACH for the Level B areas. Our challenge was to provide enough air flow to a buffer room which acted as a gateway to a Level C (Hazardous room with negative pressurization) and an ISO 8 Clean room (Positive pressurization of +25 Pa) with an interstitial ante room(with a positive pressurization +12.5Pa) in between the buffer and the ISO 8 room. The task was achieved with a 5 ton system. The hazardous room was ventilated using an exhaust fan (825 cfm @ 1.5″ ESP).
References: CSA Z317.2 Special requirements for heating, ventilation, and air-conditioning (HVAC) systems in health care facilities; ASHRAE 170 Ventilation of Health Care Facilities, ASHRAE 62.1 Ventilation for Acceptable Indoor Air Quality; HEPA High-Efficiency Particulate Air; NAPRA Guidance Document for Pharmacy Compounding of Non-sterile Preparations
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